ParkinsonCanadaV1, Main, Exploration, bibRecord, 002582

Functional abnormalities in the primary orofacial sensorimotor cortex during speech in Parkinson's disease

Identifieur interne : 002582 ( Main/Exploration ); précédent : 002581; suivant : 002583

Functional abnormalities in the primary orofacial sensorimotor cortex during speech in Parkinson's disease

Auteurs : Irena Rektorova [République tchèque] ; Jennifer Barrett [Canada] ; Michal Mikl [République tchèque] ; Ivan Rektor [République tchèque] ; Tomas Paus [Canada, Royaume-Uni]

Source :

Movement Disorders [ 0885-3185 ] ; 2007-10-31.

RBID : ISTEX:897AF6BEA47119314C32CE08B2768E58EEA5EE2E

Descripteurs français

Pascal (Inist)
- Cortex sensorimoteur, Imagerie RMN, Imagerie fonctionnelle, Maladie de Parkinson, Parole, Pathologie du système nerveux.

English descriptors

KwdEn :
- Functional imaging, Nervous system diseases, Nuclear magnetic resonance imaging, Parkinson disease, Parkinson's disease, Sensorimotor cortex, Speech, functional magnetic resonance imaging, overt reading, paralinguistic aspects of speech.

Abstract

Parkinson's disease (PD) affects speech, including respiration, phonation, and articulation. We measured the blood oxygen level‐dependent (BOLD) response to overt sentence reading in: (1) 9 treated female patients with mild to moderate PD (age; mean 66.0 ± 11.6 years, mean levodopa equivalent 583.3 ± 397.9 mg) and (2) 8 age‐matched healthy female controls (age; mean 62.2 years ± 12.3). Speech was recorded in the scanner to assess which brain regions underlie variations in the initiation and paralinguistic aspects (e.g., pitch, loudness, and rate) of speech production in the two groups. There were no differences in paralinguistic aspects of speech except for speech loudness; it was lower in PD patients compared with that in controls, when age was used as a covariate. In both groups, we observed increases in the BOLD response (reading‐baseline) in brain regions involved in speech production and perception. In PD patients, as compared with controls, we found significantly higher BOLD signal in the right primary orofacial sensorimotor cortex and more robust correlations between the measured speech parameters and the BOLD response to reading, particularly, in the left primary orofacial sensorimotor cortex. These results might reflect compensatory mechanisms and/or treatment effects that take place in mild to moderately ill PD patients with quality of speech yet comparable with that of age‐matched controls. © 2007 Movement Disorder Society

Url:

https://api-v5.istex.fr/document/897AF6BEA47119314C32CE08B2768E58EEA5EE2E/fulltext/pdf

DOI: 10.1002/mds.21548

Affiliations:

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La maladie de Parkinson au Canada (serveur d'exploration)

Functional abnormalities in the primary orofacial sensorimotor cortex during speech in Parkinson's disease

Functional abnormalities in the primary orofacial sensorimotor cortex during speech in Parkinson's disease

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	La maladie de Parkinson au Canada (serveur d'exploration)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.